Atrasentan hydrochloride

Atrasentan hydrochloride - Names and Identifiers

Name	(2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride
Synonyms	ABT-627 ABT627 ABT 627 A 147627.1 Abbott 147627 Atrasentan HCl ABBOTT 147627 Atrasentan hydrochloride Atrasentan hydrochloride (ABT-627 Atrasentan hydrochloride, CID 159595 Atrasentan hydrochloride (ABT-627 hydrochloride) (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride 3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-, monohydrochloride, (2R,3R,4S)-
CAS	195733-43-8

Atrasentan hydrochloride - Physico-chemical Properties

Molecular Formula	C29H38N2O6.HCl
Molar Mass	547.08
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
In vitro study	Atrasentan hydrochloride (ABT-627 hydrochloride) (0-50 μM) significantly inhibits LNCaP and C4-2b prostate cancer cell growth. Atrasentan profoundly induces several CYPs and drug transporters (e.g. 12-fold induction of CYP3A4 at 50 μM). It is a moderate P-gp inhibitor (IC 50 in P388/dx cells=15.1±1.6 μM) and a weak BCRP inhibitor (IC 50 in MDCKII-BCRP cells=59.8±11 μM).
In vivo study	Atrasentan hydrochloride (ABT-627 hydrochloride) (3 mg/kg, p.o.) inhibits the pressor response induced by big endothelin-1 (1 nmol/kg) in pithed rats. Aatrasentan (ABT-627, 10 mg/kg, i.p.) inhibits the C4-2b tumor growth within the bone environment to some extent in the SCID-hu model.

Atrasentan hydrochloride - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	1.828 ml	9.139 ml	18.279 ml
5 mM	0.366 ml	1.828 ml	3.656 ml
10 mM	0.183 ml	0.914 ml	1.828 ml
5 mM	0.037 ml	0.183 ml	0.366 ml

Last Update：2024-01-02 23:10:35

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CAS: 195733-43-8
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